Cytotoxic T Lymphocyte Therapy for Epstein-Barr Virus+ Hodgkin's Disease
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چکیده
منابع مشابه
Cytotoxic T Lymphocyte Therapy for Epstein-Barr Virus+ Hodgkin's Disease
Epstein Barr virus (EBV)+ Hodgkin's disease (HD) expresses clearly identified tumor antigens derived from the virus and could, in principle, be a target for adoptive immunotherapy with viral antigen-specific T cells. However, like most tumor-associated antigens in immunocompetent hosts, these potential targets are only weakly immunogenic, consisting primarily of the latent membrane protein (LMP...
متن کاملIdentification of type B-specific and cross-reactive cytotoxic T-lymphocyte responses to Epstein-Barr virus.
Persistent Epstein-Barr virus (EBV) infection is primarily controlled by HLA class I-restricted memory cytotoxic T-cell (CTL) responses which can be reactivated in vitro by stimulation of peripheral blood lymphocytes with autologous lymphoblastoid cell lines. During an investigation of a donor infected by both type A and type B EBV, CTL specific for type B EBV were isolated. The CTL were found ...
متن کاملEpstein-Barr Virus (Infectious Disease and Therapy)
Epstein-Barr virus (EBV) was the first recognized human tumor virus, but it is not the causative agent for the tumor in which it was discovered, Burkitt lymphoma. Common to all Burkitt lymphomas, endemic or sporadic, are distinctive chromosomal translocations that reactivate expression of the c-myc protooncogene and comprise the primary oncogenic mechanism. EBV is at least a contributory cofact...
متن کامل282 Epstein - Barr Virus - Specific Cytotoxic
Restriction of virus-specific cytotoxic T cell function by products of the major histocompatability complex (MHC), 1 a phenomenon first described in murine systems (1-3), has now been confirmed for the human T cell responses to antigens on cells infected by influenza (4, 5), Epstein-Barr (EB) (6, 7), and more recently, mumps (8), measles (9), and cytomegalo(10) 2 viruses. In each case the patte...
متن کاملAn Epstein-barr Virus-specific Cytotoxic
All individuals previously infected with Epstein-Barr virus (EBV) harbor life-long a population of virus-infected B cells whose number appears to be controlled by EBVspecific, HLA-restricted (class I and class II) CTLs (CD4 andCD8) that recognize a functionally defined lymphocyte-determined membrane antigen, LYDMA (1, 2) . There are two recognized types of EBV (A and B) that show sequence diver...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2004
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20040890